Diabetes Type II Diabetes surgery to correct the idea that the first in the world’s most prestigious scientific journal Annals of Surgery published their search in 1995 published by Walter Pories’s signature;
Who would mind that? (Who would have thought it?) Is discussed in scientific papers. Walter Pories follow-up of patients who underwent obesity surgery in this çalışms (14 years), the majority of patients the diabetes of about 83% and glucose intolerance, which is the 98.7% of the patients blood sugar levels have noticed the seyretdig at normal levels.
In this study, 12 of the duodenum (duodenum) and stated that the important role played by the initial portion of the small intestine after the ongoing closure of access to food in the regulation of blood sugar with the changes arising from the small intestine.
These changes and the emergence in the days immediately after the surgery because of blood sugar control is important in this period, patients lose more weight but began to decrease blood sugar. Işde an independent team of weight loss on blood sugar at this point that this improvement has been noticed that it is or may be under the influence of other factors.
Işde secreted in the intestine rather than the weight loss of the control of diabetes was recognized that these changes and the changes in a number of hormone called incretin name.
Immediately after the stomach and duodenum 12 headed continued in the early part of the small intestine theory that changes in the foregut (foregut Theory) given name. Later, Walter Pories has made a greater number of research studies confirming this.
This improvement is achieved basically three important changes in diabetes actually.
1-stomach to restrict the volume of (done a lot of work just shows that it’s even a mechanism to provide improved close to 70% of diabetes in s.)
2-stomach in the next 12 duodenum (duodenal) and after the small intestine of the initial part of the (proximal jejunum) bypass the so foods to prevent the release to continue the way from not from the small intestine into place so the hormone that rise around the secreted blood sugar such as glucagon after leaving the stomach (food here’s geçmeyince these hormones secreted is less than this region)
3-absorption of the food from the stomach without suffering much here that L cells to increase the hormone called GLP-1 secretion by enabling them to more contact with the ileum, the final section of the small intestine.
What does that excessive secretion of GLP-1?
Of blood sugar (plasma glucose of) reduction
Depending on blood sugar levels (glucose-dependent) insulin secretion that increase the secretion of insulin, so blood sugar to drop quickly
Pancreatic insulin secreting β-cells of blood glucose more excitability and responsiveness to lower blood sugar
To increase the growth of beta cells (increasing the gene expression of β-cells and differentiation)
Upgrade to suppress the blood sugar of half the glucagon hormone (suppression)
Somatostatin suppression of one of the hormones that increases the blood sugar (suppression)
increase in the number of β-cells
Extension of the β-cell survival
Non-pancreatic effect of reducing the blood sugar
Stomach (Gastric) to slow the discharge
Saturation enhancing effect of
Decrease in body weight
As a result Langerhans pancreatic hormone insulin secreting beta cells in the islets of so-called increases depending on the increase and development of beta cells. Blood glucose is under control.
And briefly summarizes all the basic mechanisms have been built on this theory. More complex are the mechanisms’ effects. Academic information entered into it after that, but I do not want to mix your head is clearly much more ….